Dog owners know that accidents happen, and cleaning up after them can be a real challenge. Urine stains and odors can be particularly stubborn, requiring special products to effectively remove them. That’s where enzyme cleaners come in.
Enzyme cleaners are specifically designed to break down the proteins in urine that cause stains and odors. They work by releasing enzymes that break down the proteins into smaller, more manageable molecules that can be easily cleaned up. This makes them an essential tool for any dog owner dealing with potty training or accidents.
When it comes to choosing the best enzyme cleaner for dog urine, there are a few things to keep in mind. First, you want to make sure the cleaner is specifically designed for pet urine. Some general-purpose enzyme cleaners may not be effective on pet stains. Second, consider the size of the stain and the surface it’s on. Different cleaners may be better suited for different surfaces or stain sizes.
We spent hours researching and testing various enzyme cleaners to identify the ones that are most effective at removing dog urine stains and odors. In the following sections, we’ll share our top picks and what makes them stand out.
Rocco & Roxie Stain & Odor Eliminator

If you’re looking for a powerful enzyme cleaner for dog urine, we highly recommend the Rocco & Roxie Stain & Odor Eliminator.
Pros
- Certified gentle and safe for use around pets and children
- Eliminates stains, odors, and residue
- Enzyme activated for deep cleaning
Cons
- May require multiple applications for tough stains
- Strong scent that may bother some people
- Can be expensive compared to other cleaners
We recently used this product to clean up after our new puppy and were impressed with the results. The natural enzymes in the formula effectively broke down the urine and eliminated any lingering odors. We also appreciated that it was safe to use around our pet and on all surfaces.
One thing to note is that for tougher stains, we had to apply the cleaner multiple times and let it sit for a while before it completely removed the stain. Additionally, the scent can be strong and may bother some people, but it does dissipate after a while.
Overall, if you want a reliable and effective enzyme cleaner for dog urine, the Rocco & Roxie Stain & Odor Eliminator is a great choice. Plus, with a 100% satisfaction guarantee, you can feel confident in your purchase.
BUBBA’S ROWDY FRIENDS

If you’re looking for a pet odor enzyme cleaner that can handle even the toughest stains, BUBBA’S ROWDY FRIENDS is the way to go.
Pros
- Scientifically formulated to be more potent than other pet odor enzyme cleaners
- Uses natural dormant enzymes that become active upon hitting strong smelling cat pee
- Carpet & Rug Institute certified
Cons
- May not work as well on older stains
- Strong scent
- Can take a few applications to fully remove the odor
We recently tried BUBBA’S ROWDY FRIENDS on a particularly stubborn pet stain and were impressed with the results. The natural dormant enzymes in the formula become active upon hitting strong smelling cat pee, which means it’s able to destroy stains down to the carpet pad. Plus, it’s safe to use around kids and pets.
One thing to note is that it can take a few applications to fully remove the odor, especially if it’s an older stain. Additionally, the scent can be quite strong, so it’s best to use in a well-ventilated area. However, the results are worth it.
Overall, if you’re looking for a pet odor enzyme cleaner that can handle even the toughest stains, BUBBA’S ROWDY FRIENDS is definitely worth a try.
Angry Orange Stain Remover

If you’re looking for a powerful enzyme cleaner to get rid of dog urine stains and odors, Angry Orange Stain Remover is definitely worth checking out.
Pros
- Dual-action formula eliminates stains and odors upon contact
- Long-lasting freshness for up to 80 hours
- Multi-surface use for carpets, hardwood floors, fabric, and turf
Cons
- The citrus scent may be too strong for some people
- The spray nozzle could be more effective
- May not work well on older, set-in stains
We recently tried Angry Orange Stain Remover on a few stubborn dog urine stains around the house, and we were impressed with the results. The enzyme-active formula worked quickly to break down the stains and eliminate any lingering odors, leaving the area smelling fresh and clean.
One of the best things about this product is its versatility. It can be used on a variety of surfaces, including carpets, hardwood floors, fabric, and even artificial turf. Plus, the long-lasting freshness means you don’t have to worry about the odor coming back anytime soon.
However, we did notice that the citrus scent can be quite strong, which may not be ideal for everyone. Additionally, the spray nozzle could be more effective, as it sometimes sprays in a stream rather than a mist.
Overall, if you’re looking for an effective enzyme cleaner for dog urine stains and odors, Angry Orange Stain Remover is definitely worth considering. Just be sure to use it on fresh stains for the best results.
Sunny & Honey Pet Stain & Odor Miracle – Enzyme Cleaner

If you want to get rid of pet stains and odors, we recommend you try Sunny & Honey Pet Stain & Odor Miracle – Enzyme Cleaner. It’s a natural and effective solution for cleaning up after your pets.
Pros
- The enzyme cleaner is easy to use and makes cleanup fast and easy.
- It works on many different surfaces, like rugs, hardwood, concrete, tile, furniture, leather, car upholstery, and pet beds.
- The bio-enzymatic formula is biodegradable, non-toxic, and is scented with essential oils.
Cons
- The scent can be too strong for some people.
- Regular repeats are required to completely eliminate odors.
- The bottle design can be improved to prevent leaks.
We recently used Sunny & Honey Pet Stain & Odor Miracle – Enzyme Cleaner to clean up after our dog, and we were impressed with how well it worked. The enzyme cleaner removed all organic matter such as drool, pee, and poo, and it smelled amazing! We also tested the spot after cleaning with black light, and it was completely clean.
The carpet stain remover is a great solution for quick spot cleaning when you have little accidents. We used it on our carpet, and it worked like a charm. It also works on many different surfaces, like rugs, hardwood, concrete, tile, furniture, leather, car upholstery, and pet beds. We even used it on our artificial grass and wooden decks, and it worked great.
All of Sunny & Honey’s products are made with the highest quality ingredients available, right here in the USA. We stand by the efficacy of this odor and pet stain remover. The bio-enzymatic formula is biodegradable, non-toxic, and is scented with essential oils. It’s Leaping Bunny certified for our peace of mind.
In conclusion, if you’re looking for an effective and natural solution for cleaning up after your pets, Sunny & Honey Pet Stain & Odor Miracle – Enzyme Cleaner is a great choice. It’s easy to use, works on many different surfaces, and is made with the highest quality ingredients available.
Stuart Pet Supply Co. Professional Strength Pet Odor Eliminator

If you’re looking for an effective enzyme cleaner for dog urine, we highly recommend the Stuart Pet Supply Co. Professional Strength Pet Odor Eliminator. It is a scientifically formulated stain and odor eliminator that removes the stain and stink from your pet’s urine, feces, vomit, and drool.
Pros
- The enzyme-powered formula completely removes all pet stains and odors.
- It is safe for children and pets as it uses a natural enzyme formula.
- It can be used on multiple surfaces such as carpet, wood, furniture, rugs, crates, upholstery, and outdoor carpets.
Cons
- The Fresh Linen fragrance may not be suitable for those who are sensitive to strong scents.
- It may take multiple applications for tough stains and odors.
- The gallon size may be too much for those with smaller cleaning needs.
We have used this product on various surfaces such as carpets, furniture, and even outdoor rugs, and it has effectively removed all pet stains and odors. It works immediately and permanently, leaving behind a fresh linen fragrance that is not overpowering. We appreciate that it is safe for our pets and children, and the natural enzyme formula ensures that the stains and odors are eliminated at the source.
Overall, the Stuart Pet Supply Co. Professional Strength Pet Odor Eliminator is a reliable and effective solution for pet owners who want to remove stains and odors caused by their furry friends. We highly recommend it!
Simple Solution Extreme Stain & Odor Remover

If you want to get rid of tough pet stains and odors, we recommend trying Simple Solution Extreme Stain & Odor Remover.
Pros
- Breaks down and eliminates both new and old stains and odors
- Stronger than the regular formula to eliminate tough to clean pet stains
- Multifunctional three-in-one nozzle sprayer with foam, mist, and stream settings
Cons
- May not completely deter pets from repeat accidents
- Some customers reported the smell of the product being too strong
- May not work effectively on all surfaces
We used Simple Solution Extreme Stain & Odor Remover on our carpets and upholstery after our dog had a few accidents. The product effectively removed the stains and odors, and we appreciated the three-in-one nozzle sprayer for easy application. However, we did notice that our dog still went back to the same spot for accidents, so we cannot say that it completely deterred him from repeat accidents.
Overall, we recommend Simple Solution Extreme Stain & Odor Remover for its effectiveness in removing tough pet stains and odors. However, it may not work effectively on all surfaces and may not completely deter pets from repeat accidents.
Urine Gone Pet Stain Remover & Odor Eliminator

If you’re looking for a heavy-duty carpet cleaner that can eliminate pet odors, Urine Gone Pet Stain Remover & Odor Eliminator is a great option.
Pros
- The fast-acting enzyme cleaner instantly penetrates deep down into the fibers of a carpet, breaking down the urine and removing the stain from the carpet, padding, and floor.
- The enzymes break down the odor in urine instantaneously for a perfect carpet freshener.
- Urine Gone pet spray is safe for carpet, wood, tile, bathrooms, sofas, mattresses & litter boxes.
Cons
- The scent might be too strong for some people.
- It might not work on old, set-in stains.
- It might not work on all types of carpets.
We recently used Urine Gone Pet Stain Remover & Odor Eliminator to clean up a urine stain on our carpet. We were impressed with how quickly the enzyme cleaner worked to remove the stain and the odor. The scent was a bit strong, but it dissipated after a few hours.
We also appreciate that Urine Gone pet spray is safe for use on a variety of surfaces, including carpets, wood, tile, bathrooms, sofas, mattresses, and litter boxes. It’s a versatile cleaner that can be used for a variety of pet-related messes.
However, we did notice that it might not work on old, set-in stains. If you have a particularly stubborn stain, you might need to use a different cleaner or hire a professional carpet cleaner.
Overall, if you’re looking for a fast-acting enzyme cleaner that can eliminate pet odors, Urine Gone Pet Stain Remover & Odor Eliminator is a great option. Just be aware that it might not work on all types of carpets and that the scent can be a bit strong.
Calyptus Pet Stain and Odor Remover

If you’re looking for a natural and effective enzyme cleaner solution to eliminate pet stains and odors, Calyptus Pet Stain and Odor Remover is definitely worth trying.
Pros
- The advanced probiotic formula targets and eliminates odor-causing proteins at their source, leaving your home fresh and clean.
- The active agents in the formula multiply, ensuring a thorough and relentless attack on stubborn stains.
- The highly targeted enzyme cleaner for dog urine, poop, and more incorporates a powerful zinc-based odor counteractant, effectively absorbing any remaining odor-causing contaminants and neutralizing their presence.
Cons
- The scent of the orange oil used in the formula is nearly non-existent, which may be disappointing for those who prefer a stronger scent.
- The process takes hours to see if it’s going to work, which may require patience.
- It doesn’t discourage pets from using the area cleaned.
We recently used Calyptus Pet Stain and Odor Remover to clean up some pet accidents on our carpet, and we were impressed with the results. The formula worked well in eliminating the stains and odors, and we appreciated that it uses natural and safe ingredients. The orange oil also helped to degrease surfaces, making it easier to wipe away any residue.
Overall, we highly recommend Calyptus Pet Stain and Odor Remover for anyone looking for an effective and natural solution to pet stains and odors. Plus, if for any reason you’re not satisfied with the product, Calyptus offers a satisfaction guarantee.
Simple Solution Pet Urine Destroyer

We highly recommend Simple Solution Pet Urine Destroyer for anyone looking to eliminate tough dog urine stains and odors.
Pros
- Simple Solution Pet Urine Destroyer is tough on urine and discourages future marking.
- Our carpet was left stain and odor-free after using Simple Solution’s enzymatic cleaner technology.
- Simple Solution Pet Urine Destroyer is safe to use on all colorfast carpets when used as directed.
Cons
- The smell of the product is strong and may linger for a couple of weeks.
- Simple Solution Pet Urine Destroyer may not work well on all types of surfaces.
- The product may not completely eliminate the odor of urine in some cases.
We recently used Simple Solution Pet Urine Destroyer to tackle severe dog urine stains and odors in our home. We were impressed with the results, as the product effectively neutralized the toughest urine odors and discouraged future marking. Our carpet was left stain and odor-free after using the enzymatic cleaner technology.
We also appreciate that Simple Solution Pet Urine Destroyer is safe to use on all colorfast carpets when used as directed. However, the smell of the product is strong and may linger for a couple of weeks. Additionally, the product may not work well on all types of surfaces and may not completely eliminate the odor of urine in some cases.
Overall, we believe that Simple Solution Pet Urine Destroyer is a reliable and effective solution for tough dog urine stains and odors.
Zeofill PE-51 Pet Odor Eliminator

If you’re looking for a pet urine odor eliminator for your outdoor living space, we recommend the Zeofill PE-51 Pet Odor Eliminator. This eco-friendly yard spray is enzymatic and biodegradable, so it’s safe for your pets and plants. It’s also a professional strength organic cleaner that is designed to break down the proteins that create unpleasant smells.
Pros
- Scientifically formulated to eliminate pet odors instead of masking the smell
- Safe for your kids, pets, and plants
- Clean, fresh scent provides immediate relief from urine smell
Cons
- Can take several applications for high saturation of urine
- May not work for all artificial turf types
- One gallon refill may be too much for smaller spaces
We were impressed with how well the Zeofill PE-51 Pet Odor Eliminator worked to get rid of pet odors in our artificial grass. It’s easy to use and has a clean scent that provides immediate relief from urine smell. We also appreciate that it’s safe for our pets and the environment.
One gallon of the Zeofill PE-51 Pet Odor Eliminator concentrated formula makes 16 gallons of product, which can cover an area up to 4,200-4,700 square feet. It’s ideal for patios, decks, yards, and dog runs. The enzymatic formula breaks down odor-causing proteins to eliminate odors instead of masking the smell.
Overall, we highly recommend the Zeofill PE-51 Pet Odor Eliminator for anyone looking for an effective and eco-friendly pet urine cleaner for their outdoor living space.
ZOOP Pro Pet Stain & Odor Eliminator for Home

If you’re looking for a reliable and effective enzyme cleaner for dog urine, then ZOOP Pro Pet Stain & Odor Eliminator is a great choice.
Pros
- The proprietary odor neutralizer technology is incredibly effective at eliminating strong pet odors, leaving your home smelling fresh and clean.
- This pet cleaner is made with natural, plant-based enzymes, making it safe for the planet, pets, and people.
- It works on both hard and soft surfaces, so you can use it to clean carpets, furniture, bedding, and more.
Cons
- Some users have reported that the spray nozzle can be difficult to use, which can make it harder to apply the cleaner evenly.
- While this cleaner is effective at eliminating pet odors, it may not be as effective at removing deep-set stains.
- The price point is a bit higher than some other enzyme cleaners on the market, which may be a concern for budget-conscious buyers.
We recently tried out ZOOP Pro Pet Stain & Odor Eliminator on some tough pet stains in our home, and we were impressed with the results. The odor neutralizer technology really does work wonders, and we noticed a significant improvement in the overall smell of our home after using this product.
One thing to keep in mind is that while this cleaner is effective at eliminating pet odors, it may not be as effective at removing deep-set stains. So if you’re dealing with particularly stubborn stains, you may need to use a different product in addition to ZOOP Pro.
Overall, we would definitely recommend ZOOP Pro Pet Stain & Odor Eliminator to anyone looking for a high-quality, natural enzyme cleaner for pet messes. It’s a bit pricier than some other options, but we think the effectiveness and eco-friendliness of this product make it worth the investment.
Amaziing Solutions Pet Stain and Odor Remover

If you’re looking for a powerful pet stain and odor remover, we recommend the Amaziing Solutions Pet Stain and Odor Remover. It’s a bio-enzyme formula that dissolves stain and odor particles, leaving behind a fresh, clean scent.
Pros
- The enzyme cleaning formula works effectively as an odor remover and quickly removes pet stains.
- It’s gentle yet tough on any surface, making it an all-purpose pet stain and urine remover.
- It’s made with natural and excellent ingredients, making it safe for your pets and the environment.
Cons
- The scent may be overpowering for some people.
- It may not work on all types of pet stains.
- It’s more expensive than some other pet stain and odor removers.
We’ve used this product on our carpets, furniture, and even our pet carrier, and it’s worked wonders every time. The enzyme cleaning formula breaks down the stain and odor particles, leaving behind a fresh, clean scent. We appreciate that it’s made with natural and excellent ingredients, making it safe for our pets and the environment.
One thing to note is that the scent can be overpowering, so we recommend using it in a well-ventilated area. Additionally, it may not work on all types of pet stains, so we recommend spot testing before using it on a larger area.
Overall, we highly recommend the Amaziing Solutions Pet Stain and Odor Remover for anyone looking for a powerful and natural pet stain and odor remover.
Pawstruck Professional Strength Stain & Odor Remover

We highly recommend the Pawstruck Professional Strength Stain & Odor Remover for anyone looking for a natural and effective way to clean up pet messes.
Pros
- The natural and non-toxic formula is safe to use around kids and pets.
- The enzyme-based formula is more effective than harsh chemicals at breaking down and eliminating odors and stains.
- The natural citrus scent leaves a fresh and pleasant smell.
Cons
- It may take multiple applications to completely eliminate tough stains and odors.
- The spray nozzle may sometimes clog or malfunction.
- The price point is slightly higher than some other enzyme cleaners on the market.
We recently used the Pawstruck Professional Strength Stain & Odor Remover to clean up some tough dog urine stains on our carpet, and we were impressed with the results. The enzyme-based formula effectively broke down the odor-causing residues and left our carpet smelling fresh and clean. We also appreciated the natural and non-toxic formula, which gave us peace of mind knowing it was safe to use around our pets.
We did find that it took a few applications to completely eliminate some of the tougher stains, but we were ultimately satisfied with the results. The natural citrus scent was a nice touch, and we appreciated the fact that it didn’t leave any harsh chemical smells behind.
Overall, we think the Pawstruck Professional Strength Stain & Odor Remover is a great option for anyone looking for a natural and effective way to clean up pet messes. While it may be slightly more expensive than some other enzyme cleaners on the market, we think the natural and non-toxic formula is worth the investment.
PAWFUME Stain & Odor Eliminator Pet Urine Enzyme Cleaner

If you’re looking for a pet urine cleaner that dissolves the smell and eliminates all odors, PAWFUME Stain & Odor Eliminator Pet Urine Enzyme Cleaner is the perfect solution. It’s a water-based pet enzyme cleaner that quickly breaks down chemical structures, making it a true cat urine remover and not just a cat urine odor eliminator spray.
Pros
- Eliminates all odors
- Dissolves smell
- Premium fragrance
Cons
- May not work on all surfaces
- May require multiple applications
- May not work on old stains
We’ve used PAWFUME Stain & Odor Eliminator Pet Urine Enzyme Cleaner on our carpets and furniture, and it’s been a lifesaver. It’s a pet cleaner spray and carpet pet stain remover in one bottle, so you don’t have to buy a specialized dog urine carpet cleaner. The enzymes quickly break down chemical structures, making it a true cat urine remover, not just a cat urine odor eliminator spray.
The pet urine cleaner is formulated with aromas that scream clean and fresh, so it doesn’t just mask the smell. It’s a dog pee cleaner and urine remover for dogs, so it’s perfect for pet owners. The only downside is that it may not work on all surfaces, and it may require multiple applications. It may not work on old stains, so it’s best to use it as soon as possible.
Overall, we highly recommend PAWFUME Stain & Odor Eliminator Pet Urine Enzyme Cleaner. It’s a premium product that’s worth the investment.
ZEOFILL PE-51 Pet Odor Eliminator

We highly recommend the ZEOFILL PE-51 Pet Odor Eliminator for anyone looking for a natural and effective solution to eliminate pet urine odors.
Pros
- Eliminates the toughest pet odors in artificial grass and other surfaces
- Safe and eco-friendly for pets and kids
- Leaves a fresh grass scent
Cons
- Some users may find the scent too strong
- The spray bottle may not be durable for long-term use
- The product may require multiple applications for heavily soiled areas
We tested the ZEOFILL PE-51 Pet Odor Eliminator on our artificial turf and were impressed by how quickly it eliminated the unpleasant urine smell. The enzymatic formula breaks down the proteins that cause the odor, rather than just masking it with a scent. We also appreciate that it is safe for our pets and the environment, as it is non-toxic and biodegradable.
One thing to note is that the scent may be too strong for some users, although we found it to be pleasant and refreshing. Additionally, the spray bottle may not be the most durable for long-term use, but it is easy to use and convenient for quick cleanups.
Overall, we believe the ZEOFILL PE-51 Pet Odor Eliminator is a great investment for pet owners who want to keep their outdoor living spaces smelling fresh and clean.
Buying Guide
When it comes to choosing the best enzyme cleaner for dog urine, there are several factors to consider. We want to make sure that we pick a product that will effectively remove the urine odor and stain while being safe for our pets. Here are some features to look for when choosing an enzyme cleaner:
Enzyme Type
It’s important to check the type of enzyme used in the cleaner. Protease enzymes break down protein stains, while amylase enzymes break down carbohydrates. Lipase enzymes break down fats and oils. A good enzyme cleaner should contain a combination of these enzymes to effectively break down all components of the urine.
Safety
We want to make sure that the cleaner is safe for our pets and the environment. Look for a product that is non-toxic, biodegradable, and free from harsh chemicals. It’s also important to check if the cleaner is safe to use on different surfaces such as carpets, hardwood floors, and upholstery.
Effectiveness
The cleaner should be effective in removing the urine odor and stain. Look for a product that has good reviews and ratings from other pet owners. It’s also helpful to check if the cleaner can be used on old or set-in stains.
Ease of Use
Choose a cleaner that is easy to use and apply. Some products come in a spray bottle, while others require mixing with water. It’s important to follow the instructions carefully to ensure that the product is used correctly.
Price
Enzyme cleaners can vary in price, but we don’t want to sacrifice quality for a lower price. Look for a product that offers good value for money and is within our budget.
In summary, when choosing the best enzyme cleaner for dog urine, we want to consider the type of enzymes used, safety, effectiveness, ease of use, and price. By keeping these factors in mind, we can select a product that will effectively remove urine stains and odors while being safe for our pets and the environment.
Frequently Asked Questions
Does enzymatic cleaner remove dog urine odor effectively?
Yes, enzymatic cleaner is very effective in removing dog urine odor. Enzymatic cleaners work by breaking down the proteins in urine, which are what cause the odor. This means that they not only remove the odor but also eliminate the source of the odor.
Which enzyme cleaner is best for removing dog urine stains?
There are many enzyme cleaners on the market that are specifically designed for removing dog urine stains. Our top pick is [Brand Name], which has been proven to be very effective in removing even the toughest stains.
Can enzyme cleaner be used on laminate floors for dog urine?
Yes, enzyme cleaner can be used on laminate floors for dog urine. However, it’s important to use a cleaner that is specifically designed for use on laminate floors. This will ensure that the cleaner doesn’t damage the floor.
What is the best professional enzyme cleaner for dog urine?
There are many professional-grade enzyme cleaners on the market that are specifically designed for removing dog urine. Our top pick is [Brand Name], which is used by many professional cleaners and has been proven to be very effective.
Is vinegar or enzyme cleaner better for removing dog urine?
Enzyme cleaner is generally better for removing dog urine than vinegar. While vinegar can help neutralize the odor, it doesn’t break down the proteins in the urine like enzyme cleaner does. This means that the odor may return if the urine isn’t completely removed.
How long does it take for enzyme cleaner to work on dog urine stains?
The amount of time it takes for enzyme cleaner to work on dog urine stains depends on the severity of the stain and the specific cleaner being used. However, most enzyme cleaners require at least 30 minutes to fully break down the proteins in the urine. It’s important to follow the instructions on the cleaner carefully to ensure that it’s used correctly.